Verapamil HCl
Verapamil hydrochloride
CAS: 23313-68-0;152-11-4
Molecular Formula: C27H39ClN2O4
Verapamil HCl - Names and Identifiers
Verapamil HCl - Physico-chemical Properties
| Molecular Formula | C27H39ClN2O4 |
| Molar Mass | 491.06 |
| Melting Point | 142°C (dec.)(lit.) |
| Boling Point | 586.1°C at 760 mmHg |
| Flash Point | 308.3°C |
| Water Solubility | soluble |
| Solubility | H2O: >30 mg/mL |
| Vapor Presure | 1.01E-13mmHg at 25°C |
| Appearance | White to off-white powder |
| Color | white |
| Storage Condition | 0-6°C |
| MDL | MFCD00055208 |
| Use | For organic synthesis, pharmaceutical industry; Mainly used for paroxysmal supraventricular tachycardia, but also for angina, hypertension and hypertrophic infarction cardiomyopathy |
Verapamil HCl - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | YV8320000 |
| FLUKA BRAND F CODES | 8-10 |
Verapamil HCl - Reference
| Reference Show more | 1. Li Tao, Zhao Xiaoliang, Nie Yinglan, et al. Study on Brain Permeability of Sinomenine and Ligustrazine in CQ Analgesic Compound [J]. Journal of Pharmacy 2019 v.54(12):186-193. 2. Pan Jie, Yang Shuting, Sun Jia, et al. Study on Intestinal Absorption Characteristics of Six Active Components in Hongcao in Normal and Myocardial Ischemia Model Rats [J]. Chinese Pharmacy, 2020(13). 3. Zhang Yu, Ban Yujuan, Wang Zhongyuan, Zhang Li, Tang Lei, Liao Weike. Transport Characteristics of New DPP-4 Inhibitor LGT-6 in Caco-2 Cell Monolayer Model [J]. Chemical reagent, 2021,43(04):434-440. 4. Huang, Yuanjia, et al. "Molecular cloning and characterization of calmodulin-like protein CaLP from the Scleractinian cord Galaxea astreata." Cell Stress and Chaperones 23.6 (2018): 1329-1335.https:// doi.org/10.1007/s12192-018-0907-0 5. [IF = 6.4] Jing Zhao et al. "Natural Nano-Drug Delivery System in Coptidis Rhizoma Extract with Modified Berberine Hydrochloride Pharmacokinetics." Int J Nanomed. 2021; 16: 6297-6311 6. [IF = 5.81] Zhao Jing et al. "Intra-Herb Interactions: primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice." Front Pharmacol. 2021 Jun;0:1426 7. [IF = 4.36] Guanghou Wang et al. "Simultaneous determination of 11 alkaloids in rat plasma by LC-ESI-MS/MS and a pharmacokinetic study after oral administration of total alkaloids extracted from Nauclea officinalis." J Ethnopharmacol 2022 Jan;282:114560 |
Verapamil HCl - Standard
Authoritative Data Verified Data
This product is (±)-a-[3-[[2-(3, 4-dimethoxyphenyl) ethyl] methylamino] propyl]-3, 4-dimethoxy-isopropylphenylacetonitrile hydrochloride. The content of C27H38N204 • HC1 shall not be less than 98.5% calculated as dry product.
Last Update：2024-01-02 23:10:35
Verapamil HCl - Trait
Authoritative Data Verified Data
- This product is white powder; Odorless.
- This product is soluble in the fermentation, ethanol or chloroform, dissolved in water.
melting point
The melting point of this product (General 0612) is 141~145°C.
Last Update：2022-01-01 15:34:04
Verapamil HCl - Differential diagnosis
Authoritative Data Verified Data
- take the product of aqueous solution (1-20)2ml, add 5 drops of ammonium chromium thiocyanate solution, that is, the formation of light red precipitate.
- take this product, add water to dissolve and dilute to make a solution containing about 0401 mg per lml, and measure by UV-Vis spectrophotometry (general rule), there is a maximum absorption at the wavelength of 229nm and 278nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 389).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:34:05
Verapamil HCl - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, add water to dissolve 20ml, and then determine it according to law (General rule 0631). The pH value should be 4.5~6.5.
clarity of the solution
take l.Og of this product, add water 20ml to dissolve, the solution should be clear.
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing about 2.5mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of each of the test solution and the control solution are accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
residual solvent
take this product about 0.1g, precision weighing, top empty bottle, precision plus N, N-dimethylformamide 1ml, sealed, as a test solution; Take ethanol, acetone, benzaldehyde, dimethyl sulfoxide, toluene, three gas methane appropriate amount, precision weighing, with N, N-dimethylformamide quantitative dilution made per lml containing ethanol, acetone, benzaldehyde, dimethyl sulfoxide were 0.5mg, toluene 89ug, chloroform 6ug of mixed solution, precision take 1ml, empty bottle, sealed, as a reference solution.
Test as residual solvent assay (General 0861 second method). 6% cyanopropylphenyl-94% dimethylpolysiloxane (or polar similar) as the stationary liquid; The initial temperature is 40°C, maintained for 3 minutes, and the temperature is raised to 100°C at a rate of 3°C per minute, the temperature was then increased to 240°C at a rate of 30°C per minute for 3 minutes; The inlet temperature was 150°C; The detector temperature was 280°C; The headspace bottle equilibrium temperature was 90°C, and the equilibrium time was 30 minutes. Take the reference solution into the headspace, the separation degree between the peaks of each component shall meet the requirements. Then the sample solution and the reference solution were injected with headspace, and the chromatogram was recorded. According to the external standard method to calculate the peak area, the residual amount of benzaldehyde shall not exceed 0.5%, ethanol, acetone, dimethyl sulfoxide, toluene and chloroform residues shall be in accordance with the provisions.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
l.Og of this product shall be taken and inspected according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
The residue left under the item of burning and flooding shall be inspected according to law (general law 0821, Law II) and shall not contain more than 10 parts per million of heavy metals.
Last Update：2022-01-01 15:34:06
Verapamil HCl - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel was bonded with octa-alkyl silane as filler; Acetic acid-sodium acetate solution (sodium acetate 1.36g, add appropriate amount of water, shake to dissolve, add 33ml of glacial acetic acid, dilute to 1000ml with water, shake well)-methanol-triethylamine (55:45:1) as mobile phase; Column temperature 40°C; Detection wavelength was 278Mn. The theoretical plate number is not less than 2000 calculated as the verapamil peak.
assay
take an appropriate amount of this product, precision weighing, plus mobile phase dissolution and quantitative dilution to make a solution containing about 0.25mg per lml, precision measurement of 20 u1, injection of human liquid chromatography, record the chromatogram; another Verapamil hydrochloride reference substance, precision weighing, the same method for determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 15:34:06
Verapamil HCl - Category
Authoritative Data Verified Data
calcium channel blockers.
Last Update：2022-01-01 15:34:06
Verapamil HCl - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 15:34:07
Verapamil HCl - Verapamil hydrochloride tablets
Authoritative Data Verified Data
This product contains Verapamil hydrochloride (C27H38N204 • HCI) should be 90.0% ~ 110.0% of the label amount.
trait
This product is sugar-coated tablets, White after removing the coating.
identification
- take an appropriate amount of fine powder of this product (about 0.lg of Verapamil hydrochloride), add 5ml of water, shake to dissolve Verapamil hydrochloride, filter, filtrate under the identification of Verapamil hydrochloride (1), (4) the test showed the same response.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- for related substances, take the continued filtrate under the content determination item as the test solution; Take 1ml of precision measurement, put it in a 100ml measuring flask, dilute to the scale with mobile phase, and shake well, as a control solution. The determination was carried out according to the method for related substances of Verapamil hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- dissolution of this product, according to the dissolution and release determination method (General 0931 second method), hydrochloric acid solution (9- 1000)900ml as the dissolution medium, the rotation speed is 50 rpm, and the operation is carried out according to law. After 45 minutes, the solution is filtered, and the filtrate is taken as UV-visible spectrophotometry (General rule 0401), the absorbance was measured at the wavelength of 278nm and 300nm respectively; The reference substance of Verapamil hydrochloride was weighed accurately, dissolved and quantitatively diluted with dissolution medium to make a solution containing about 4ug per lml, and the same method was used for determination, the absorbance difference (AA) was determined, and the elution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, remove the coating, precision weighing, fine grinding, precision weighing an appropriate amount (about 0.125g equivalent to Verapamil hydrochloride), put it in a 50ml measuring flask, and add an appropriate amount of mobile phase, shake to dissolve Verapamil hydrochloride and dilute to the scale, shake well, filter, Take 5ml of continuous filtrate accurately, put it in 50ml measuring flask, dilute to the scale with mobile phase, shake well, as a test solution. According to the method of Verapamil hydrochloride content determination, according to the external standard method to calculate the peak area, that is.
category
Same as Verapamil hydrochloride.
specification
40mg
storage
sealed preservation
Last Update：2022-01-01 15:34:07
Verapamil HCl - Verapamil hydrochloride injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of Verapamil hydrochloride. Containing Verapamil hydrochloride (C27H38N204 • HCl) shall be between 93.0% and 107.0% of the labeled amount.
trait
This product is a clear colorless liquid.
identification
after the product was dried by evaporation on a water bath, the same results were shown in the tests (1), (2) and (4) under the item of residual submerged irradiation of Verapamil hydrochloride.
examination
- the pH value should be 4.0 to 6.0 (General 0631).
- Related substances take this product as a test solution; Take 1 ml with precision, put it in a 100ml measuring flask, dilute it to the scale with mobile phase, shake well, and use it as a control solution. The determination was carried out according to the method for related substances of Verapamil hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- The endotoxin in the fine seedling is taken and checked according to law (General rule 1143). The amount of endotoxin contained in 1 mg Verapamil hydrochloride should be less than 7.5EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take an appropriate amount of this product (about 12.5mg equivalent to Verapamil hydrochloride), put it in a 50ml measuring flask, dilute it to the scale with mobile phase, and shake it well to serve as a test solution. According to the method of Verapamil hydrochloride content determination, according to the external standard method to calculate the peak area, that is.
category
Same as Verapamil hydrochloride.
specification
2ml:5mg
storage
light shielding, closed storage.
Last Update：2022-01-01 15:34:08
Verapamil HCl - Verapamil hydrochloride sustained-release tablets
Authoritative Data Verified Data
This product contains Verapamil hydrochloride (C27H38N204 • HCl) should be 93.0% ~ 107.0% of label amount.
trait
This product is white-like tablets.
identification
- take an appropriate amount of fine powder of this product (about 0.lg equivalent to Verapamil hydrochloride), add 5ml of water, shake to dissolve Verapamil hydrochloride, filter, filtrate under the identification of Verapamil hydrochloride (1), (4) the test showed the same response.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- the dissolution of this product, according to the dissolution and release determination method (General rule 09 31 second method), with water 1000ml as the dissolution medium, the speed is 50 rpm, according to the law, after 2 hours, 6 hours and 12 hours, take 10ml of the solution respectively, filter and immediately supplement the dissolution medium of the same temperature and the same volume, and take 5ml of the continued filtrate respectively, A solution containing about 20ug of Verapamil hydrochloride per 1 ml was prepared by quantitative dilution with water, and the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (general). The elution amount of each tablet at different times was calculated as the absorption coefficient of C27H38N204-HCl was 313. The dissolution amount of each tablet of this product at 2 hours, 6 hours and 12 hours shall be 20% ~ 45%, 45% ~ 70% and more than 70% of the labeled amount respectively, and shall comply with the regulations.
- Related substances take an appropriate amount of fine powder of this product (about 25mg of Verapamil hydrochloride), put it in a 10ml measuring flask, use an appropriate amount of mobile phase, ultrasonic to dissolve Verapamil hydrochloride and dilute it to the scale, shake it well, filter, take the filtrate as a test solution; Take 1ml of precision, 100ml flask, diluted with mobile phase to the scale, shake, as a control solution. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area (1.0%) of the control solution, determined according to the method for related substances of Verapamil hydrochloride.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 25mg equivalent to Verapamil hydrochloride), put it in a 100ml measuring flask, add an appropriate amount of mobile phase, ultrasonic dissolution of Verapamil hydrochloride and diluted to scale, shake, filter, take the filtrate as a test solution. According to the method of Verapamil hydrochloride content determination, according to the external standard method to calculate the peak area, that is.
category
Same as Verapamil hydrochloride.
specification
120mg
storage
sealed storage.
Last Update：2022-01-01 15:34:09
Supplier List
Multiple SpecificationsSpot supply
Product Name: (±)-Verapamil hydrochloride Visit Supplier Webpage Request for quotationCAS: 152-11-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: (±)-Verapamil hydrochloride Visit Supplier Webpage Request for quotationCAS: 152-11-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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